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BHS-Sonthofen Inc. • 14300 South Lakes Drive, Charlotte, North Carolina 28273-6794 • Phone: 704-845-1190 • Fax: 704-845-1902

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Process Design Strategy: The Advantages of Continuous Filtration for Pharmaceutical Manufacturing

Process Design Strategy: The Advantages of Continuous Filtration for Pharmaceutical Manufacturing

The advantages of continuous manufacturing in the chemical industry have been realized for decades. In comparison to batch processing, these advantages include smaller space requirements, lower capital, better quality, higher yield, and improved health and safety concerns among many others. The regulatory environment and relatively smaller scale operations has hindered the development of these types for processes in the pharma industry. However recently, many industry leaders are beginning to push the development of new regulatory compliant continuous processes for manufacturing active pharmaceutical ingredients. Three case studies are examined showing how continuous filtration can be implemented successfully in the pharmaceutical industry and how the design strategy can be modified to accommodate the specific needs of the process. The result is a much more efficient and reliable separation process that is also compliant with all quality and regulatory requirements.

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